Endocrine Abstracts

Mineralocorticoid Receptor (MR) is able to regulate the transcription of a number of genes in the myotube, nevertheless the role of this steroid hormone receptor in skeletal muscle (SM) metabolism needs to be clarified. SM represents a major site for glucose uptake and local metabolic derangements play a pivotal role in the development of insulin resistance (IR). The aim of this study was to investigate the contribution of MR in mediating SM metabolic alterations in a mouse mo...

Objective: higher aldosterone (aldo) levels are associated with increased risk of cardiovascular ischemic events and mortality. It has been demonstrated that aldo accelerates the development of aterosclerosis in apolipoprotein E knockout mice (ApoE KO). Ketogenic diet (KD) positively impacts several cardiovascular risk factors, yet its effect on atherosclerosis, is elusive. We hypothesize that, KD protects from development of atherosclerotic plaques in ApeE KO mice, a murine m...